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some transgender people (shemales) are born male with a penis, but they know that they should have been born female, so they take feminizing medicines to make them more feminine
and
some transgender people (hefemales) are born female with a vagina, but they know that they should have been born male, so they take masculinizing medicine to make them more masculine
It must be a small niche but one if you market correctly can end in good sales numbers, it is similar to the cross dressing niche, small but productive.